Correction to Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor
نویسندگان
چکیده
Tyrosine Kinase Inhibitor Hyung-Gu Kim, Li Tan, Ellen L. Weisberg, Feiyang Liu, Peter Canning, Hwan-Geun Choi, Scott Ezell, Zheng Zhao, Hong Wu, Jinhua Wang, Anna Mandinova, Alex N. Bullock,* Qingsong Liu,* Sam W. Lee,* and Nathanael S. Gray* ACS Chem. Biol. 2013, 8, 2145−2150. I the reported X-ray cocrystal structure of the DDR1 kinase domain in complex with the inhibitor DDR1-IN-1 (PDB code 4BKI), the indolin-2-one moiety was modeled with two hydrogen bonds to the kinase hinge residues Met704 and Asp702. Subsequent analysis of the electron density has revealed that the indolin-2-one group is flipped allowing only a single hydrogen bond to Met704. The amended coordinates have been released with the new PDB code 4CKR. The corrected Figure 2A is shown, together with the
منابع مشابه
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عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2014